The Paul Feder Laboratory for Reaearch on Neurodegenerative diseases
Our research focuses on both basic and translational neuroscience. We study the roles of innate immune receptors of the Toll-like receptors / Interleukin-1 pathways on spatial learning and memory in rodents, with emphasis on spatial pattern completion and pattern separation. In this respect, we also study spatial learning and memory in human subjects using virtual reality environments.
In addition, We study possible mechanisms by which adult neurogenesis, the process of formation of new neurons in the adult brain, can be further enhanced.
On the translation branch of the laboratory, we develop a DNA vaccination strategy to delay the progression of Alzheimer's disease using mouse models of Alzheimer's disease and Down syndrome. In addition, we also develop biomarkers for earlier diagnosis of neurodegenerative disorders such as Alzheimer's disease and Parkinson’s disease.