ד"ר ניסן יששכר

Publications list:

• Naim G*, Romano H*, Amidror S*, Jessula Levy D, Cohen A, Sochen C, Gilberg H, Farah N, Rudenko V, Yarden Y, Feng M, Tsentsarevsky R, Brodie Z, Reich Y, Simon A, Toister E, Shoval I, Armon L, Schiller M, Mandel Y, Biton M, and Yissachar N. # Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis. Nature Communications. (2025).
• Hegelmaier T, et al., Segal E, Yissachar N #, Haghikia A #. Supplementation with short-chain fatty acids and the prebiotic 2FL improves clinical outcome in PD. Scientific Reports. (2025).
• Dürholz K, et al., Yissachar N, Schett G, Rothhammer V, Zaiss M. Gut-specific H3R signaling orchestrates microglia-dependent resolution of peripheral inflammation. Journal of Clinical Investigations (2025).
• Romano-Zadaka H and Yissachar N #. From Microbiota to Menu: Predicting Individual Responses to Dietary Components. Gut (2025).
• Goldberg K, Weizmann T, Antonello P, Yakir I, Ulman A, Lobov A, Sheban D, Shmueli MD, Laser E, Kramer M, Shteinvil R, Chen G, Shimshi S, Ogneva K, Amidror S, Bootz-Maoz H, Dezorella N, Yoskovitz V, Kacen A, Lau GW, Yissachar N, Hayouka Z and Merbl Y. Proteasome-derived defense peptides facilitate cell-autonomous innate immunity against pathogens. Nature (2025).
• Agranyoni O, Sur D, Amidror A, Shidlovsky N, Bagaev A, Yissachar N, Pinhasov A, Navon-Venezia S. Colon Impairments and Inflammation Driven by an Altered Gut Microbiome Leads to Social Behavior Deficits Rescued by Hyaluronic acid and Celecoxib. BMC Medicine (2024)
• Bootz-Maoz H, Simon A, Del Mare-Roumani S, Bennet Y, Toister E, Romano H, Zheng D, Amidror S, Elinav E and Yissachar N. # Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics. npj Biofilms and Microbiomes (2023)
• Bootz-Maoz H*, Pearl A*, Melzer E*, Malnick S*, Sharon E, Bennet Y, Tsentsarevsky R, Abuchatzera S, Amidror S, Aretz E, Azriel S, Gam Ze Letova C, Naama M, Shoval I, Yaron O, Karako-Lampert S, Bel S and Yissachar N. # Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome. Cell Reports (2022)
• Sassone-Corsi M, Azriel S, Simon S, Ramanan D, Ortiz-Lopez A, Chen F, Yissachar N, Mathis D and Benoist C. Avoidance of T cell activation by sequestering gut pathobionts in intraluminal casts. PNAS (2022)
• Monzani R, Gagliardi M, Clemente N, Saverio V, Pańczyszyn E, Santoro C, Yissachar N, 
  Visciglia A, Pane M, Amoruso A and Corazzari M. The Gut-Ex-Vivo System (GEVS) is a dynamic and versatile tool for the study of DNBS-induced IBD in BALB/C and C57BL/6 mice, highlighting the protective role of probiotics. Biology. (2022).
• Azriel S, Bootz H, Shemesh A, Amidror S, and Yissachar N. # An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions. J. Vis. Exp. (2021).
• Gagliardi M, Monzani R, Clemente N, Fusaro L,  Saverio V, Grieco G, Pańczyszyn E, Yissachar N,  Boccafoschi F, Corazzari M. A Gut-Ex-Vivo system to study gut inflammation associated to Inflammatory Bowel Disease (IBD). Biology. (2021).
• Gagliardi M, Clemente N, Monzani R, Fusaro L, Ferrari E, Saverio V, Grieco G, Pańczyszyn E, Carton F, Santoro C, Del Mare-Roumani S, Amidror S, Yissachar N, Boccafoschi F, Zucchelli S and Corazzari M. Gut-Ex-Vivo system as a model to study gluten response in celiac disease. Cell Death Discovery. 7:45 (2021).
• Grosheva I, Zheng D, Levy M, Polansky O, Lichtenstein A, Golani O, Dori-Bachash M, Moresi C, Shapiro H, Del Mare-Roumani S, Valdes-Mas R, He Y, Karbi H, Chen M, Harmelin A, Straussman R, Yissachar N, Elinav E, and Geiger B. High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function. Gastroenterology. 159(5):1807-1823 (2020)
• Chen Z, Zhou R, Zhang Y, Hao D, Wang Y, Huang S, Liu N, Xia C, Yissachar N, Huang F, Chu Y, and Yan D. β-Arrestin 2 Quenches TLR Signaling to Facilitate the Immune Evasion of EPEC. Gut Microbes. 1:1423-1437 (2020)
• Duscha A*, Gisevius B*, Hirschberg S*, Yissachar N*, et al., Linker RA, Gold R, and Haghikia A. Propionic acid shapes the course of multiple sclerosis by a distinct immunomodulatory mechanism. Cell. 180(6):1067-1080 (2020).
• Yissachar N. # Ménage à trois: regulation of host immunity by enteric neuro-immune-microbiota cross talks. Current Opinion in Neurobiology. 62:26-33. (2019)

• Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D and Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 168:1135-1148 (2017)

  » This work was highlighted by Ivanov, Trends in Immunology (2017)

  » This work was highlighted by Thomas, Nature Reviews Gastro. and Hepato. (2017)

  » This work was recommended in F1000 Prime (2017)

• Yissachar N*, Sharar-Fischler T*, Cohen AA, Reich-Zeliger S, Russ D, Shifrut E, Porat Z and Friedman N. Dynamic response diversity of NFAT isoforms in individual living cells. Molecular Cell. 49:322-30 (2013)     

  » This work was highlighted by Kalo and Shav-Tal, Genome Biology 14:102 (2013)

• Ndifon W*, Gal H*, Shifrut E, Aharoni R, Yissachar N, Waysbort N, Reich-Zeliger S, Arnon R and Friedman N. Chromatin conformation governs T cell receptor Jβ gene segment usage. PNAS. 109:15865-70 (2012)
• Salem H*, Rachmin I*, Yissachar N*, Cohen S, Amiel A, Haffner R, Lavi L and Motro B. Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy. Oncogene. 29:4046-57. (2010)     
• Noy-Lotan S, Dgany O, Lahmi R, Marcoux N, Krasnov T, Yissachar N, Ginsberg D, Motro B, Resnitzky P, Yaniv I, Kupfer GM and Tamary H. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. Haematologica. 94:629-37. (2009)
• Yissachar N, Salem H, Tennenbaum T and Motro B. Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. FEBS Letters. 580:6489-95. (2006)
• Feige E, Shalom O, Tsuriel S, Yissachar N and Motro B. Nek1 shares structural and functional similarities with NIMA kinase. BBA - Molecular Cell Research. 1763:272-81. (2006)

Chapters in books:

• Partney H and Yissachar N. Chapter: Regulation of Host Immunity by the Gut Microbiota. Book: Evolution, biodiversity, and a reassessment of the hygiene hypothesis. Series: Progress in inflammation research. Springer-Nature. (2022)