Dr. Linda Rubinstein

Position- Principal Investigator, Director of Research, The Joseph Sagol Neuroscience Center

Summary

Dr. Rubinstein’s lab aims to elucidate how environmental stressors and aging affect the brain and behavior. We use cutting edge behavioral and molecular methods to illuminate redox and immune dys-homeostasis in neurodegenerative disorders and in aging. We are particularly interested to uncover sex differences in neurodegeneration and neuro-inflammation. By combining behavioral cues and molecular markers, we aim to find early biomarkers predicting neuropathology. We work with in vivo transgenic animal models, as well as in vitro models, we also use extreme environments as a model for accelerated aging. Our research is relevant to neuroinflammatory pathologies including cancer, inflammaging, Alzheimer’s, Parkinson’s, ALS, MS, and depression.

Overall, our research aims to advance more inclusive predictive and personalized medicine.

Education

Affiliations

*The Joseph Sagol Neuroscience Research Center, Sheba

*The Longevity Center, Sheba

*The Multidisciplinary Gonda Brain Research Center, Bar Ilan

Research Interests

• Elucidate redox and immune dys-homeostasis in neurodegenerative diseases and in aging.
• Find early biomarkers and behavioural cues for neurodegeneration.
• Immune and redox modulation as a possible therapy for neurodegenerative pathologies
• Sex-differences in neurodegeneration and neuro-inflammation
• Underlying mechanisms of how environmental stressors affect brain and behaviour.
• Using extreme environments (e.g. space) as a model for accelerated aging.
• Space medicine, astrobiology, and space research