פרופ' אלון קורנגרין

English שלחו לחבר
  • ראש המרכז לחקר המוח
  • ראש מעבדת מחקר
קורות חיים

השכלה:   

תואר ראשון           בן-גוריון בנגב                 כימיה                   1991
תואר שני               בן-גוריון בנגב                 כימיה                   1993
תואר שלישי           בן-גוריון בנגב                 כימיה                   1997
פוסט-דוקטורט       מכון מקס פלנק             פיזיולוגיה              1997-2001

תעסוקה:

מרצה              אוניברסיטת בר-אילן             2001

מרצה-בכיר      אוניברסיטת בר-אילן             2007

פרופ׳ חבר       אוניברסיטת בר-אילן             2012

פרופ׳ מלא        אוניברסיטת בר-אילן            2018

 

מחקר

We study some of the basic yet still unresolved questions in neuroscience: How do neurons process information? What is the neuronal code at the cellular level? How does synaptic integration affect neuronal computation? To address these questions we combine electrophysiology of neurons in acute brain slices with techniques in computational neuroscience. Over the past decade, we have developed several computational techniques aiming at constraining numerical models for complex cortical neurons. Thus, our research has aspects from computer science, neuronal computation, biophysics, and neurophysiology. We are currently working on two primary projects that investigate various aspects of the general questions we are interested in.

פרסומים

 

  1. Korngreen, A. and Priel, Z. (1994) Simultaneous measurement of intracellular calcium and ciliary beating. Biophys. J. 67, 377-380.

  2. Tarasiuk, A., Bar-Shimon, M., Gheber, L., Korngreen, A., Grossman, Y. and Priel, Z. (1995) Extracellular ATP induces hyperpolarization and motility stimulation of ciliary cells. Biophys. J. 68, 1163-1169.

  3. Alfahel, E., Korngreen, A., Parola, A.H. and Priel, Z. (1996) Purinergically induced membrane fluidization in ciliary cells: characterization and control by calcium and membrane potential. Biophys. J. 70, 1045-1053.

  4.  Korngreen, A. and Priel, Z. (1996) Purinergic stimulation of rabbit ciliated airway epithelia: control by multiple calcium sources. J. Physiol. (Lond.) 497, 53-66.

  5. Korngreen, A., Gold’shtein, V. and Priel, Z. (1997) Realistic modeling of biphasic calcium transients in electrically nonexcitable cells. Biophys. J. 73, 659-673.

  6. Gheber, L., Korngreen, A. and Priel, Z. (1998) Effect of viscosity on metachrony in mucus propelling cilia. Cell Motil. Cytoskeleton 39, 9-20.

  7. Korngreen, A. and Priel, Z. (1998) Mucus transporting cilia: A model system for investigating calcium signaling in electrically inexcitable cells. In: Cilia, Mucus, and Mucociliary Interactions. Marcel Dekker, NY, pp. 49-58.

  8.  Korngreen, A., Ma, W., Priel, Z. and Silberberg, S.D. (1998) Extracellular ATP directly gates a cation-selective channel in rabbit airway ciliated epithelial cells. J. Physiol. (Lond.) 508, 703-720.

  9.  Weiyuan, M., Korngreen, A., Uzlaner, N., Priel, Z. and Silberberg, S.D. (1999) Extracellular Na+ regulates airway ciliary motility by inhibiting a P2X receptor. Nature 400, 894-897.

  10.  Korngreen, A. and Sakmann, B. (2000) Voltage gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. J. Physiol. 525, 621-639.

  11. Silberberg, S.D., Korngreen, A., Ma, W., Uzlaner, N. and Priel, Z.  (2001) Modulation of ciliary motility by Na+ In: Cilia and Mucus: From Development to respiratory defense. Marcel Dekker, NY, pp. 81-90.

  12. Gensler, S., Sander, A., Korngreen, A., Traina, G., Giese, G. and Witzemann, V. (2001).  Acetylcholine receptor- and -subunits tagged with green fluorescent protein are incorporated at the neuromuscular junction in vivo.  Eur. J. Biochem. 268, 2209-2217.

  13.  Schaefer, A.T., Helmstaedter, M., Sakmann, B. and Korngreen, A. (2003) Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels.  Biophys. J. 84, 3508-3528.

  14. Korngreen, A., Kaiser, KMM.,  Zilberter Y. (2005) Subthreshold Inactivation of Voltage-gated K+ Channels Modulates Action Potentials in Neocortical Bitufted Interneurones J. Physiol. 562, 421-437.

  15. Peter, C., Korngreen, A. and Witzemann, V. (2005). Mutation of single murine acetylcholine receptor subunits reveals differential contribution of P121 to acetylcholine binding and to channel opening.  Pflug. Arch. Eur. J. Physiol. 450, 178–184.

  16.  Keren, N. Peled, N. and Korngreen A. (2005). Constraining compartmental models using multiple voltage-recordings and genetic algorithms. J. Neurophysiol. 94: 3730-3743

  17. Ma, W., Korngreen, A., Weil, S., Ben-Tal Cohen, E., Priel, A., Kuzin, L., Silberberg, SD. (2006). Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells. J. Physiol. 571: 503-517. 

  18. Gurkiewicz, M., Korngreen, A. (2006) Recording, Analysis and Function of Dendritic Voltage-Gated Channels. Pflug. Arch. Eur. J. Physiol.  453: 283-292

  19.  Schaefer, AT., Helmstaedter, M., Schmitt, AC., Bar-Yehuda, D., Almog, M., Ben-Porat, H., Sakmann, B. and Korngreen, A (2007) Dendritic voltage-gated K+ conductance gradient in neocortical pyramidal neurones. J. Physiol. 579: 737-752

  20. Michaelevski, I., Korngreen A., and Lotan, I. (2007) Interaction of syntaxin 1A with a presynaptic voltage-gated K+ channel: a possible mechanism for modulation of synaptic integration. Pflug. Arch. Eur. J. Physiol.  454:477-494

  21.  Gurkiewicz, M., and Korngreen, A. (2007). A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm. PLoS Comp Biol 3(8): e169.

  22. Segev D., and Korngreen, A. (2007). Kinetics of two voltage-gated K+ conductances in substantia nigra dopaminergic neurons. Brain Res 1173: 27-35.

  23. Bar-Yehuda, D., and Korngreen, A. (2007). Cellular and network contributions to excitability of layer 5 neocortical pyramidal neurons in the rat PLoS ONE 2(11): e1209

  24. Hurwitz, I., Ophir, A., Korngreen, A., Koester, J., and Susswein AJ. (2008) Currents Contributing to Decision-Making in Neurons B31/B32 of Aplysia. J. Neurophysiol. 99: 814–830.

  25. Bar-Yehuda, D., and Korngreen, A. (2008). Space clamp problems when voltage clamping neurons expressing voltage-gated conductances. J. Neurophysiol 99: 1127–1136.

  26. Pomp O, Brokhman I, Ziegler L, Almog M, Korngreen A, Tavian M, Goldstein RS. (2008) PA6-induced human embryonic stem cell-derived neurospheres: a new source of human peripheral sensory neurons and neural crest cells. Brain Res. 1230:50-60.

  27.  Bar-Yehuda D., Hana Ben-Porat, H., and Korngreen A. (2008) Dendritic excitability during increased synaptic activity in rat neocortical L5 pyramidal neurons European Journal of Neuroscience, 28, 2183–2194.

  28.  Keren, N., Bar-Yehuda, D., and Korngreen, A. (2009) Experimentally guided modeling of dendritic excitability in rat neocortical pyramidal neurons. J. Physiol. 587: 1413-1437.

  29. Almog, M. and Korngreen, A. (2009) Characterization of voltage-gated Ca2+ channels in layer 5 neocortical pyramidal neurons from rats PLoS ONE, 4:e4841.

  30. Regev N, Degani-Katzav N, Korngreen A, Etzioni A, Siloni S, Alaimo A, Chikvashvili D, Villarroel A, Attali B, Lotan I, (2009) Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity. PLoS ONE 4(8): e6586.

  31. Bronfeld M, Belelovsky K, Erez Y, Bugaysen J, Korngreen A, Bar-Gad I. (2010) Bicuculline induced chorea manifests in focal rather than globalized abnormalities in the activation of the external and internal globus pallidus. J Neurophysiol. 104(6):3261-75.

  32. Bugaysen J, Bronfeld M, Tischler H, Bar-Gad I, Korngreen A. (2010) Electrophysiological characteristics of globus pallidus neurons. PLoS One 5(8): e12001.

  33. Tischler, H., Wolfus, S., Friedman, A., Perel, E., Pashut, T., Lavidor, M., Korngreen A., Yeshurun, Y, Bar-Gad, I. (2011) Mini-coil for magnetic stimulation in the behaving primate, J. Neurosci Methods. 15; 194(2): 242-51.

  34.  Gurkiewicz M, Korngreen A, Waxman SG, Lampert A. (2011). Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation.  Journal of Neurophysioloy 105(4): 1546-57.

  35.  Pashut, T., Wolfus, S. Friedman, A., Lavidor, M. Bar-Gad, I. Yeshurun, Y., and Korngreen A. (2011) Mechanisms of magnetic stimulation of central nervous system neurons.  PLoS Computational Biology 7(3): e1002022

  36. Bugaysen J, Bar-Gad I and Korngreen A (2011). The impact of stimulation induced short-term synaptic plasticity on firing patterns in the globus pallidus of the rat. Frontiers in Systems Neuroscience 5:16.

  37. Berger, U., Korngreen, A., Bar-Gad, I., Friedman A., Wolfus, S., Yeshurun, Y., and Lavidor M. (2011) Magnetic stimulation intensity modulates motor inhibition. Neuroscience Letters. 504(2): 93-7.

  38. Ben-Shalom R, Aviv A Razon, B. and Korngreen A. (2012) Optimizing ion channel kinetics using a massively parallel genetic algorithm on a graphical processing unit. Journal of Neuroscience Methods. 15;206(2):183-94

  39. Tischler, H. Moran A, Belelovsky K, Bronfeld M, Korngreen A, Bar-Gad I. (2012) Changes in basal ganglia processing of cortical input following magnetic stimulation in Parkinsonism Neurobiology of disease      48, 464-473

  40. Ben-Shalom R, Liberman G, Korngreen A. (2013) Accelerating compartmental modeling on a graphical processing unit. Front Neuroinform.18;7:4.

  41. Bugaysen J, Bar-Gad I, Korngreen A. (2013) Continuous modulation of action potential firing by a unitary GABAergic connection in the globus pallidus in vitro. J Neurosci. 31;33(31):12805-9

  42. M Brody, and Korngreen. A. (2013) Simulating the effects of short-term synaptic plasticity on postsynaptic dynamics in the globus pallidus Front. Syst. Neurosci., 08 August 2013 7:40,1-11 | doi: 10.3389/fnsys.2013.00040

  43. Lavian H, Ben Porat H and Korngreen A (2013) High and low frequency stimulation of the subthalamic nucleus induce prolonged changes in subthalamic and globus pallidus neurons. Front. Syst. Neurosci. 7:73,1-8. doi: 10.3389/fnsys.2013.00073

  44. Tzachi Sabati; Bat-Sheva Galmidi; Alon Korngreen; Naomi Zurgil; Mordechai Deutsch J.Real-time monitoring of changes in plasma membrane potential via imaging of fluorescence resonance energy transfer at individual cell resolution in suspension Biomed. Opt. 18 (12), 126010 (December 16, 2013); 18. 126010-20

  45. Almog M, Korngreen A. (2014) A quantitative description of dendritic conductances and its application to dendritic excitation in layer 5 pyramidal neurons. J Neurosci. 2014 Jan 1;34(1):182-96.

  46. Pashut T, Magidov D, Ben-Porat H, Wolfus S, Friedman A, Perel E, Lavidor, M, Bar-Gad I, Yeshurun Y and Korngreen A (2014) Patch-clamp recordings of rat neurons from acute brain slices of the somatosensory cortex during magnetic stimulation. Front. Cell. Neurosci. 8:145. 1-12 doi: 10.3389/fncel.2014.0014

  47. Lavian H, Korngreen A. (2015). Inhibitory short-term plasticity modulates neuronal activity in the rat entopeduncular nucleus in vitro. Eur J Neurosci. 2015 May 25. doi: 10.1111/ejn.12965. 

  48. Almog M, Korngreen A. (2016) Is realistic neuronal modeling realistic? J Neurophysiol. 116(5):2180-2209

  49. Korngreen A.(2017) Visualizing fundamental neuronal computation for life science students. Adv Physiol Educ.41(2):312-314 

  50. Lavian H, Almog M, Madar R, Loewenstern Y, Bar-Gad I, Okun E, Korngreen A. (2017) Dopaminergic Modulation of Synaptic Integration and Firing Patterns in the Rat Entopeduncular Nucleus. J Neurosci.37(30):7177-7187